The COL13A1 Polyclonal Antibody (PAC003450) is a valuable tool for researchers studying COL13A1, a collagen protein that plays a role in cell adhesion and tissue development. Raised in rabbits, this antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to the COL13A1 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for research in areas such as tissue engineering, wound healing, and developmental biology.COL13A1 is an important component of the extracellular matrix and is involved in processes such as cell migration, adhesion, and differentiation.
Its role in tissue development and integrity makes it a key target for studies on skin disorders, connective tissue diseases, and developmental abnormalities. By investigating the function of COL13A1, researchers can gain insight into how alterations in this protein may contribute to various pathological conditions and potentially inform the development of targeted therapies.
Antibody Name:
COL13A1 Antibody
Antibody SKU:
PACO03450
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human COL13A1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
COL13A1; Collagen alpha-1(XIII) chain; COLXIIIA1
UniProt Protein Function:
COL13A1: Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. 10 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 10q22Cellular Component: collagen type XIII; endoplasmic reticulum lumen; extracellular region; intercellular junction; plasma membraneMolecular Function: heparin binding; protein bindingBiological Process: cell differentiation; cell-cell adhesion; cell-matrix adhesion; collagen catabolic process; endochondral ossification; extracellular matrix disassembly; extracellular matrix organization and biogenesis; morphogenesis of a branching structure
UniProt Protein Details:
NCBI Summary:
This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whether this trimer is composed of one or more than one alpha chain isomer. A number of alternatively spliced transcript variants have been described, but the full length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
