The COL25A1 Polyclonal Antibody (PACO05524) is a valuable tool for research studies involving COL25A1, a type XXV collagen protein associated with various biological processes such as cell adhesion, migration, and angiogenesis. This antibody, developed through immunization of rabbits, exhibits high specificity and sensitivity for detecting COL25A1 in human samples.COL25A1 is known for its involvement in extracellular matrix formation and organization, with potential implications in tissue development and repair. The COL25A1 Polyclonal Antibody is optimized for use in Western blotting applications, enabling researchers to analyze COL25A1 expression levels in different cell types and tissues.
By targeting COL25A1, researchers can gain insights into its role in various physiological and pathological conditions, including cancer, cardiovascular diseases, and connective tissue disorders. The ability to accurately detect and quantify COL25A1 expression opens up opportunities for further understanding its functions and potential therapeutic applications in these disease contexts.
COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4q25Cellular Component: extracellular space; collagen; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane; extracellular regionMolecular Function: heparin binding; beta-amyloid bindingBiological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesisDisease: Fibrosis Of Extraocular Muscles, Congenital, 5
UniProt Protein Details:
NCBI Summary:
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
