The COL5A3 Polyclonal Antibody (PACO06368) is a valuable tool for researchers studying COL5A3, a key component of type V collagen, an important structural protein in connective tissues. This antibody, generated in rabbits, has high specificity and sensitivity for detecting COL5A3 in human samples, making it suitable for various applications including Western blotting.COL5A3 is essential for maintaining the integrity and strength of tissues such as skin, ligaments, and blood vessels.
Dysregulation of COL5A3 has been implicated in various connective tissue disorders and diseases, making it a promising target for therapeutic interventions. By utilizing the COL5A3 Polyclonal Antibody, researchers can investigate the role of COL5A3 in physiological and pathological conditions, advancing our understanding of connective tissue biology and potential treatment strategies.
Synthesized peptide derived from the N-terminal region of human COL5A3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 cells using COL5A3 Polyclonal Antibody.
Western Blot analysis of K562 cells using COL5A3 Polyclonal Antibody.
Synonyms:
COL5A3; Collagen α-3(V) chain
UniProt Protein Function:
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
UniProt Protein Details:
NCBI Summary:
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]
