The COQ4 Polyclonal Antibody (PAC042726) is a valuable tool for researchers studying COQ4, a protein involved in the biosynthesis of coenzyme Q, an essential component of the electron transport chain in mitochondria. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.COQ4 is a key player in the synthesis of coenzyme Q, which is crucial for cellular energy production and oxidative stress protection. Dysregulation of COQ4 has been linked to a variety of diseases, including mitochondrial disorders and neurodegenerative conditions.
By targeting COQ4 with this antibody, researchers can further investigate its role in mitochondrial function and potential therapeutic applications in mitochondrial-related diseases.Overall, the COQ4 Polyclonal Antibody is a reliable tool for studying the biological function of COQ4 and its implications in mitochondrial health. Researchers in the fields of biochemistry, cell biology, and mitochondrial research will find this antibody useful for their studies on energy metabolism and mitochondrial dysfunction.
Antibody Name:
COQ4 Antibody (PACO42726)
Antibody SKU:
PACO42726
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial protein (31-265AA)
Immunohistochemistry of paraffin-embedded human liver tissue using PACO42726 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO42726 at dilution of 1:100.
Background:
Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
Synonyms:
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog), COQ4
UniProt Protein Function:
COQ4: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. Belongs to the COQ4 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 9q34.11Cellular Component: mitochondrionBiological Process: ubiquinone biosynthetic processDisease: Coenzyme Q10 Deficiency, Primary, 7
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
