The COX16 Polyclonal Antibody (PAC013907) is a valuable tool for researchers studying COX16, a protein involved in the assembly of cytochrome c oxidase, an essential enzyme in cellular respiration. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the COX16 protein, this antibody allows for the accurate detection and analysis of COX16 levels in various cell types, making it ideal for research in the fields of biochemistry and mitochondrial biology.COX16 plays a crucial role in the biogenesis of cytochrome c oxidase, a key enzyme in the electron transport chain that is vital for ATP production in cells.
Dysregulation of COX16 has been linked to mitochondrial dysfunction and energy metabolism disorders, making it a target of interest for studies on mitochondrial diseases and metabolic disorders. By gaining a better understanding of COX16 function, researchers can uncover new insights into cellular respiration and potentially develop novel therapeutic strategies for mitochondrial-related conditions.
Antibody Name:
COX16 Antibody (PACO13907)
Antibody SKU:
PACO13907
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:500-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human COX16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13907(COX16 Antibody) at dilution 1/50. (Original magnification: x200).
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO13907(COX16 Antibody) at dilution 1/50. (Original magnification: x200).
Background:
This protein is encoded by COX16, corresponding to the previously uncharacterized open reading frame YJL003w of the yeast genome. COX16 was identified in studies of COX-deficient mutants previously assigned to complementation group G22 of a collection of yeast pet mutants. To determine its location, Cox16p was tagged with a Myc epitope at the C terminus.
Synonyms:
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
UniProt Protein Function:
COX16: Belongs to the COX16 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 14q24.2Cellular Component: mitochondrial membrane; integral to membrane
