The Cox19 Polyclonal Antibody (PACO36062) is specifically designed for research involving Cox19, a protein involved in the assembly and maintenance of mitochondrial respiratory chain complexes. This antibody, raised in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.Cox19 is a crucial protein in the mitochondria, essential for proper electron transport chain function and ATP production. Dysregulation of Cox19 has been implicated in mitochondrial disorders and diseases related to mitochondrial dysfunction.
The Cox19 Polyclonal Antibody enables the detection and analysis of Cox19 expression in various cell types, making it an ideal tool for researchers in the fields of mitochondrial biology and related diseases.Understanding the role of Cox19 in mitochondrial function is essential for developing targeted therapies for mitochondrial disorders and other conditions related to mitochondrial dysfunction. The Cox19 Polyclonal Antibody is a valuable asset for studies aiming to unravel the complexities of mitochondrial biology and its implications in human health.
Antibody Name:
COX19 Antibody (PACO36062)
Antibody SKU:
PACO36062
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cytochrome c oxidase assembly protein COX19 protein (8-90AA)
Immunofluorescent analysis of HepG2 cells using PACO36062 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be required for the assembly of mitochondrial cytochrome c oxidase.
Synonyms:
Cytochrome c oxidase assembly protein COX19 (hCOX19), COX19
UniProt Protein Function:
COX19: May be required for the assembly of mitochondrial cytochrome c oxidase. Belongs to the COX19 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7p22.3Cellular Component: cytoplasm; mitochondrial intermembrane space; cytosolBiological Process: aerobic respiration; mitochondrial respiratory chain complex IV assembly
UniProt Protein Details:
NCBI Summary:
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
