The COX6B2 Polyclonal Antibody (PAC014281) is specifically designed for research involving COX6B2, a subunit of cytochrome c oxidase (Complex IV) that plays a crucial role in the electron transport chain of mitochondria. The antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the COX6B2 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in mitochondrial biology and respiratory chain function.COX6B2, a key component of the respiratory chain enzyme complex, is essential for the proper function of mitochondria in generating ATP through oxidative phosphorylation. Dysregulation of COX6B2 expression or function has been linked to mitochondrial dysfunction and various human diseases, including neurodegenerative disorders and metabolic syndromes.
Investigating the role of COX6B2 in mitochondrial electron transport is crucial for understanding the pathophysiology of these conditions and developing potential therapeutic interventions targeting mitochondrial function.By utilizing the COX6B2 Polyclonal Antibody in your research, you can gain valuable insights into the molecular mechanisms underlying mitochondrial respiration and its impact on cellular energy production. This antibody offers reliable performance and specificity, making it an invaluable tool for scientists studying mitochondrial biology, bioenergetics, and related fields.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO14281(COX6B2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14281(COX6B2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO14281(COX6B2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Cytochrome c oxidase is the terminal enzyme of the electron transfer chain in aerobic bacteria as well as in the mitochondria of plants and animals. Bacterial cytochrome c oxidases are composed of three different subunits and include two hemes a and two copper atoms as prosthetic groups. The enzyme from eukaryotes is more complex and includes three subunits encoded on mitochondrial DNA, which are the homologues of the subunits of the bacterial enzyme, and in addition contains a number of subunits encoded in the nucleus. It is generally agreed that the mitochondrially coded subunits with their associated prosthetic groups are the functional core of the enzyme. The role of the nuclear coded subunits in cytochrome c oxidase function remains a matter of conjecture. cytochrome c oxidase subunit VIb polypeptide 2 Connects the two COX monomers into the physiological dimeric form.
Synonyms:
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
UniProt Protein Function:
COX6B2: Connects the two COX monomers into the physiological dimeric form. Belongs to the cytochrome c oxidase subunit 6B family.
UniProt Protein Details:
Protein type:Oxidoreductase; Cancer Testis Antigen (CTA); Mitochondrial
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: mitochondrial crista; mitochondrial intermembrane space
