The COX7B Polyclonal Antibody (PACO08555) is a valuable tool for researchers studying COX7B, a subunit of cytochrome c oxidase (CcO) involved in the electron transport chain of the mitochondria. This antibody, produced in rabbits, has a high specificity for human samples and is validated for use in Western blot applications. By binding to the COX7B protein, this antibody allows for the precise detection and analysis of COX7B in a variety of cell types, making it an excellent choice for studies in mitochondrial function, energy metabolism, and respiratory chain biology.COX7B is essential for the proper function of CcO, the final enzyme complex in the electron transport chain responsible for ATP production in aerobic respiration.
Dysregulation of COX7B has been linked to mitochondrial dysfunction, energy deficits, and various diseases, including metabolic disorders and neurodegenerative conditions. Research on COX7B is vital for understanding cellular respiration, mitochondrial health, and the pathogenesis of related disorders. By studying COX7B, researchers can gain insights that may lead to the development of therapies targeting mitochondrial dysfunction and associated diseases.
COX7B: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.Protein type: Membrane protein, integral; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: Xq21.1Cellular Component: mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activityBiological Process: cellular metabolic process; central nervous system development; transmembrane transportDisease: Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism, And Other Congenital Anomalies
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
