The Cox7B Antibody (PAC013910) is a valuable tool for researchers investigating the role of Cox7B in cellular function. Cox7B is a subunit of cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain responsible for energy production in cells. This polyclonal antibody, produced in rabbits, is highly specific to Cox7B and is validated for use in various applications, including Western blotting and immunofluorescence.By targeting Cox7B, researchers can study the function of this subunit in mitochondrial metabolism and its potential implications in diseases such as cancer, metabolic disorders, and neurodegenerative diseases.
Understanding the role of Cox7B can provide valuable insights into cellular bioenergetics and offer potential therapeutic targets for various health conditions. The Cox7B Antibody offers researchers a reliable tool to probe the function of this important mitochondrial protein in their studies.
Gel: 10+15%SDS-PAGE, Lysate: 50 μg, Lane: 293T cells, Primary antibody: PACO13910(COX7B Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO13910(COX7B Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.
Synonyms:
Cytochrome c oxidase subunit VIIb
UniProt Protein Function:
COX7B: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.Protein type: Membrane protein, integral; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: Xq21.1Cellular Component: mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activityBiological Process: cellular metabolic process; central nervous system development; transmembrane transportDisease: Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism, And Other Congenital Anomalies
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
