The COX7B2 Polyclonal Antibody (PAC013915) is a valuable tool for researchers studying the role of COX7B2 in cellular respiration and mitochondrial function. COX7B2 is a subunit of cytochrome c oxidase (complex IV) in the electron transport chain, playing a crucial role in ATP production and energy metabolism. This antibody, produced in rabbits, is highly specific and reactive to human samples, making it ideal for Western blot analysis. By binding to COX7B2 protein, the antibody allows for the detection and quantification of COX7B2 levels in various cell types and tissues.
Research on COX7B2 is important for understanding mitochondrial bioenergetics and its implications in diseases such as mitochondrial disorders, metabolic syndromes, and neurodegenerative conditions. The COX7B2 Polyclonal Antibody can provide valuable insights into the function and regulation of this essential mitochondrial protein, aiding in the development of potential therapeutic strategies targeting mitochondrial dysfunction.
Antibody Name:
COX7B2 Antibody (PACO13915)
Antibody SKU:
PACO13915
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human COX7B2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13915(COX7B2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO13915(COX7B2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. The COX7B2 gene encodes an 80-residue protein and has a 499-bp mRNA transcript. The COX7B2 gene contains 3 exons and maps to chromosome 4p12. For a discussion of a possible association between variation in the COX7B2 gene and susceptibility to the development of nasopharyngeal carcinoma, see NPCA1.
Synonyms:
cytochrome c oxidase subunit VIIb2
UniProt Protein Function:
COX7B2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.Protein type: Membrane protein, integral; Mitochondrial; OxidoreductaseChromosomal Location of Human Ortholog: 4p12Cellular Component: integral to membrane; mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activity
