The CPNE8 Polyclonal Antibody (PAC02288) is a valuable tool for researchers studying CPNE8, a calcium-dependent membrane-binding protein involved in various cellular processes. This antibody is produced in rabbits and has been validated for use in Western blot applications, with high reactivity towards human samples. By binding to the CPNE8 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it ideal for studies in molecular biology and cell signaling pathways.CPNE8 is known to play a role in intracellular calcium signaling and membrane trafficking, making it a key player in cellular homeostasis and communication.
Its involvement in these processes suggests potential implications in disease mechanisms, making it an attractive target for research in fields such as neuroscience, cell biology, and developmental biology. Understanding the function of CPNE8 is essential for unraveling its contribution to disease pathology and for developing targeted therapeutic interventions.
Antibody Name:
CPNE8 Antibody (PACO22288)
Antibody SKU:
PACO22288
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from N-terminal of human CPNE8.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CPNE8 antibody.
Background:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties By similarity.
Synonyms:
copine VIII; copine-8;
UniProt Protein Function:
CPNE8: a member of the copine protein family with calcium-dependent phospholipid binding properties. Copines are ubiquitously expressed, phospholipid-binding proteins that have been conserved through evolution. Highest expression of CPNE8 mRNA is seen in the prostate, heart, and brain. Fusion to AML1 in a t(12;21) translocation causes aggressive acute myelogenous leukemia. Two alternatively spliced isoforms have been described.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q12
UniProt Protein Details:
NCBI Summary:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
