The CREB3 Antibody (CAB6567) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.CREB3, also known as cAMP-responsive element-binding protein 3, is a key player in cellular responses to various stress stimuli, including endoplasmic reticulum stress and viral infections. Its involvement in these processes makes it a significant target for studies in cell biology, virology, and disease pathogenesis.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
CREB3 Antibody
SKU:
CAB6567
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Cytoplasm, Endoplasmic Reticulum Membrane, Membrane, Nucleus, Single-Pass Type Ii Membrane Protein.
Calculated MW:
41kDa
Observed MW:
41kDa
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
Purification Method
Affinity purification
Gene ID
10488
RRID
AB_2767161
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CREB3 Rabbit pAb (CAB6567) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Immunofluorescence analysis of NIH/3T3 cells using CREB3 Rabbit pAb (CAB6567) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
