The CRIM1 Polyclonal Antibody (PACO19512) is a powerful tool for researchers studying CRIM1, a cell surface protein involved in various biological processes, including development and disease. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards CRIM1 in human samples, making it an ideal choice for Western blot experiments.CRIM1, also known as cysteine-rich motor neuron 1 protein, is known to play a crucial role in cell growth, differentiation, and tissue morphogenesis. It has been implicated in numerous diseases, including cancer and developmental disorders.
By targeting CRIM1 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications.This antibody offers researchers the opportunity to explore the role of CRIM1 in different cell types and biological pathways, making it a valuable tool for studies in developmental biology, cancer research, and regenerative medicine. Its ability to detect CRIM1 protein expression with high specificity will undoubtedly enhance the understanding of this protein's involvement in various physiological and pathological processes.
Antibody Name:
CRIM1 Antibody (PACO19512)
Antibody SKU:
PACO19512
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human CRIM1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19512(CRIM1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19512(CRIM1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor β family, such as bone morphogenetic proteins.
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
