The CSGALNACT1 Polyclonal Antibody (PACO04727) is an essential tool for researchers studying CSGALNACT1, a key enzyme involved in the biosynthesis of chondroitin sulfate proteoglycans (CSPGs). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.CSGALNACT1 plays a crucial role in the synthesis of CSPGs, which are important components of the extracellular matrix and play a significant role in cell signaling, cell adhesion, and tissue development.
Abnormalities in CSGALNACT1 expression have been linked to various diseases, including cancer and neurological disorders.By using the CSGALNACT1 Polyclonal Antibody, researchers can detect and analyze the expression of CSGALNACT1 in different cell types and tissues, providing valuable insights into its function and potential implications in disease pathogenesis. This antibody is a valuable tool for studies in the fields of glycosylation, extracellular matrix biology, and disease mechanisms involving CSPGs.
Antibody Name:
CSGALNACT1 Antibody
Antibody SKU:
PACO04727
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Beta-1,4-GalNAc-T.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ChGn: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.4.1.174Chromosomal Location of Human Ortholog: 8p21.3Cellular Component: Golgi membrane; intracellularMolecular Function: acetylgalactosaminyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; glucuronosyltransferase activity; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; peptidoglycan glycosyltransferase activityBiological Process: chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process; proteoglycan biosynthetic process; UDP-glucuronate metabolic process; UDP-N-acetylgalactosamine metabolic process
