The CSN2 Polyclonal Antibody (CAB12749) is a valuable tool for research involving CSN2, a protein linked to various biological processes, including cell growth and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CSN2 protein, researchers can detect and analyze its expression in different cell types, making it an excellent choice for studies in molecular biology and cancer research.
CSN2, also known as COP9 signalosome complex subunit 2, plays a crucial role in regulating protein degradation and is involved in pathways that control cell cycle progression and DNA repair. Its involvement in these cellular processes underscores its significance as a potential therapeutic target for diseases like cancer and neurodegenerative disorders. Investigating the functions of CSN2 is essential for uncovering potential treatments that target its activity for therapeutic purposes.
Product Name:
CSN2 Rabbit Polyclonal Antibody
SKU:
CAB12749
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSN2 (NP_001882.1).
This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. In addition, the C-terminal 14 aa of the protein has antimicrobial activity, especially in preterm milk, displaying antibacterial activity against S. aureus and Y. enterocolitica. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1447
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using CSN2 Rabbit pAb (CAB12749) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
