The Cystatin M Polyclonal Antibody (CAB8115) is a valuable tool for researchers studying Cystatin M, a protein involved in regulating protease activity and maintaining tissue homeostasis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in a variety of applications, including Western blotting.Cystatin M is a member of the cystatin superfamily, which plays a crucial role in controlling the activity of cysteine proteases. Dysregulation of cystatin M has been implicated in various diseases, including cancer and neurodegenerative disorders.
By using the Cystatin M Polyclonal Antibody, researchers can study the expression and function of this protein in different cell types, helping to further our understanding of its role in health and disease.Overall, the Cystatin M Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complex role of cystatin M in human biology and disease pathology. Its high specificity and sensitivity make it an ideal choice for studies in molecular biology, biochemistry, and drug development.
Product Name:
CST6 Rabbit Polyclonal Antibody
SKU:
CAB8115
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-149 of human CST6 (NP_001314.1).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.
Purification Method:
Affinity purification
Gene ID:
1474
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CST6 antibody (CAB8115) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
