The CUTC Antibody (PACO58508) is a valuable tool for researchers studying CUTC, a protein involved in copper transport and homeostasis within cells. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CUTC protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in biochemistry and metal metabolism research.CUTC plays a crucial role in maintaining copper balance in the body, and its dysfunction has been associated with copper-related disorders such as Menkes disease and Wilson disease.
By understanding the function and regulation of CUTC, researchers can gain insights into the mechanisms underlying these conditions and explore potential therapeutic interventions. The CUTC Antibody (PACO58508) offers a reliable tool for investigating the role of CUTC in copper metabolism and related pathologies, paving the way for innovative approaches to disease treatment and management.
IHC image of PACO58508 diluted at 1:400 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO58508 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO58508 diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
Synonyms:
Copper homeostasis protein cutC homolog, CUTC
UniProt Protein Function:
CUTC: a copper binding protein associated with copper homeostasis and transport. Widely expressed in human tissues. Its nuclear and cytoplasmic distribution suggests that it may be a nucleocytoplasmic copper ion shuttle protein.Protein type: CarrierChromosomal Location of Human Ortholog: 10q24.2Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: copper ion binding; protein bindingBiological Process: protein tetramerization
UniProt Protein Details:
NCBI Summary:
Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]
