Description
CYFIP2 Antibody (PACO16099)
The CYFIP2 Polyclonal Antibody (PAC016099) is a valuable tool for researchers studying the CYFIP2 protein, which plays a key role in neuronal development and synaptic function. This antibody is raised in rabbits and has been validated for use in Western blot applications, showing high reactivity with human samples.CYFIP2 is a critical component of the WAVE regulatory complex, which is involved in actin polymerization and cytoskeletal dynamics necessary for proper neuronal function. Dysregulation of CYFIP2 has been linked to neurodevelopmental disorders such as autism spectrum disorder and intellectual disabilities.
By targeting the CYFIP2 protein, researchers can gain insights into the mechanisms underlying these disorders and potentially identify novel therapeutic targets. The CYFIP2 Polyclonal Antibody is a reliable tool for investigating the role of CYFIP2 in neurological development and may contribute to the development of treatments for neurodevelopmental disorders.
| Antibody Name: | CYFIP2 Antibody (PACO16099) |
| Antibody SKU: | PACO16099 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human CYFIP2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16099(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: PACO16099(CYFIP2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16099(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid, protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
| Synonyms: | cytoplasmic FMR1 interacting protein 2 |
| UniProt Protein Function: | CYFIP2: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. Belongs to the CYFIP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: neuron projection; membrane; perinuclear region of cytoplasm; cytoplasm; synapse; cell junction; cytosol Molecular Function:protein binding Biological Process: cell-cell adhesion; positive regulation of proteolysis; apoptosis; innate immune response; vascular endothelial growth factor receptor signaling pathway |
| UniProt Code: | Q96F07 |
| NCBI GenInfo Identifier: | 134034199 |
| NCBI Gene ID: | 26999 |
| NCBI Accession: | Q96F07.2 |
| UniProt Related Accession: | Q96F07 |
| Molecular Weight: | |
| NCBI Full Name: | Cytoplasmic FMR1-interacting protein 2 |
| NCBI Synonym Full Names: | cytoplasmic FMR1 interacting protein 2 |
| NCBI Official Symbol: | CYFIP2Â Â |
| NCBI Official Synonym Symbols: | EIEE65; PIR121Â Â |
| NCBI Protein Information: | cytoplasmic FMR1-interacting protein 2 |
| UniProt Protein Name: | Cytoplasmic FMR1-interacting protein 2 |
| UniProt Synonym Protein Names: | p53-inducible protein 121 |
| Protein Family: | Cytoplasmic FMR1-interacting protein |
| UniProt Gene Name: | CYFIP2Â Â |
| UniProt Entry Name: | CYFP2_HUMAN |
