Description
CYP2A13 Antibody (PACO64657)
The CYP2A13 Polyclonal Antibody (PACO64657) is a valuable tool for researchers studying the CYP2A13 enzyme, which is involved in the metabolism of various compounds, including nicotine and certain carcinogens. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.CYP2A13 is a member of the cytochrome P450 superfamily of enzymes, which play a crucial role in the detoxification and activation of xenobiotics in the body. This particular enzyme is predominantly expressed in the respiratory tract and is known to be involved in the bioactivation of tobacco-specific nitrosamines, making it a potential target for studying the link between tobacco smoking and lung cancer.
By utilizing the CYP2A13 Polyclonal Antibody, researchers can detect and analyze the expression of the CYP2A13 enzyme in various cell types and tissues, enabling further exploration into its role in chemical metabolism and its potential implications for human health. This antibody is essential for investigations in toxicology, pharmacology, and cancer research, providing valuable insights into the mechanisms underlying drug metabolism and chemical carcinogenesis.
| Product Name: | CYP2A13 Antibody |
| Product Code: | PACO64657 |
| Size: | 50µL |
| Target Names: | CYP2A13 |
| Species Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Antigen Species: | Human |
| Tested Applications: | ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:100-1:500 |
| Isotype: | IgG |
| Clone ID: | N/A |
| Conjugate: | Non-conjugated |
| Clonality: | Polyclonal |
| Antigen: | Recombinant Human Cytochrome P450 2A13 protein (252-354aa) |
| Form: | Liquid |
| Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Storage: | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Aliases: | Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13), CYP2A13 |
| Uniprot ID: | Q16696 |
| Background: | Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. |
| Research Area: | Cardiovascular |
