Description
CYP2S1 Antibody (PACO00667)
The CYP2S1 Polyclonal Antibody (PACO00667) is a valuable tool for researchers studying the cytochrome P450 family member CYP2S1. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CYP2S1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies within the fields of drug metabolism, toxicology, and cancer research.CYP2S1 is an important enzyme involved in the metabolism of various endogenous compounds and xenobiotics, playing a crucial role in the detoxification and activation of a wide range of substances.
Its expression and activity have been implicated in drug metabolism pathways as well as in the development and progression of certain types of cancer. By studying the function of CYP2S1, researchers can gain valuable insights into its role in drug metabolism, toxicology, and disease pathogenesis, potentially leading to the development of novel therapeutic strategies.
| Antibody Name: | CYP2S1 Antibody |
| Antibody SKU: | PACO00667 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human CYP2S1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CYP2S1; Cytochrome P450 2S1; CYPIIS1 |
| UniProt Protein Function: | CYP2S1: Has a potential importance for extrahepatic xenobiotic metabolism. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm Molecular Function:iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96SQ9 |
| NCBI GenInfo Identifier: | 48428134 |
| NCBI Gene ID: | 29785 |
| NCBI Accession: | Q96SQ9.2 |
| UniProt Secondary Accession: | Q96SQ9,Q9BZ66, |
| UniProt Related Accession: | Q96SQ9 |
| Molecular Weight: | 504 |
| NCBI Full Name: | Cytochrome P450 2S1 |
| NCBI Synonym Full Names: | cytochrome P450, family 2, subfamily S, polypeptide 1 |
| NCBI Official Symbol: | CYP2S1Â Â |
| NCBI Official Synonym Symbols: | CYPIIS1Â Â |
| NCBI Protein Information: | cytochrome P450 2S1; cytochrome P540, subfamily IIS, polypeptide 1 |
| UniProt Protein Name: | Cytochrome P450 2S1 |
| UniProt Synonym Protein Names: | CYPIIS1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2S1Â Â |
| UniProt Entry Name: | CP2S1_HUMAN |
