Description
CYP2U1 Antibody (PACO00668)
The CYP2U1 Polyclonal Antibody (PACO00668) is a vital tool for researchers studying the cytochrome P450 family member CYP2U1, an enzyme involved in the metabolism of various endogenous and exogenous compounds. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CYP2U1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in pharmacology, toxicology, and drug metabolism.
CYP2U1 is known for its role in lipid metabolism and its potential impact on diseases such as neurodegenerative disorders and metabolic syndromes. Understanding the function and regulation of CYP2U1 is essential for developing therapeutic strategies that target this enzyme, making this antibody a crucial resource for researchers aiming to unravel the complexities of drug metabolism and disease pathogenesis.
| Antibody Name: | CYP2U1 Antibody |
| Antibody SKU: | PACO00668 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human CYP2U1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CYP2U1; Cytochrome P450 2U1 |
| UniProt Protein Function: | CYP2U1: Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Oxidoreductase; Membrane protein, integral; EC 1.14.14.1; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 4q25 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane Molecular Function:iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; oxygen binding Biological Process: organic acid metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process Disease: Spastic Paraplegia 56, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z449 |
| NCBI GenInfo Identifier: | 74762432 |
| NCBI Gene ID: | 113612 |
| NCBI Accession: | Q7Z449.1 |
| UniProt Secondary Accession: | Q7Z449,Q96EQ6, B2RMV7, |
| UniProt Related Accession: | Q7Z449 |
| Molecular Weight: | 18,578 Da |
| NCBI Full Name: | Cytochrome P450 2U1 |
| NCBI Synonym Full Names: | cytochrome P450, family 2, subfamily U, polypeptide 1 |
| NCBI Official Symbol: | CYP2U1Â Â |
| NCBI Official Synonym Symbols: | SPG49; SPG56; P450TECÂ Â |
| NCBI Protein Information: | cytochrome P450 2U1; spastic paraplegia 49 |
| UniProt Protein Name: | Cytochrome P450 2U1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2U1Â Â |
| UniProt Entry Name: | CP2U1_HUMAN |
