Description
CYP2U1 Antibody (PACO22049)
The CYP2U1 Polyclonal Antibody (PAC022049) is a valuable tool for researchers studying the cytochrome P450 family member CYP2U1. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CYP2U1 protein, this antibody allows for the detection and analysis of CYP2U1 expression in a variety of cell types, making it ideal for investigations in drug metabolism, toxicology, and neurology.CYP2U1 is an important enzyme involved in the metabolism of various endogenous compounds and xenobiotics, including fatty acids and drugs.
Its role in drug metabolism makes it a key player in pharmacokinetics and drug interactions, while its potential involvement in neurological disorders like Parkinson's disease and schizophrenia has sparked interest in its functions in the central nervous system. Research on CYP2U1 could lead to insights into personalized medicine and the development of novel therapeutic strategies for neurological conditions.
| Antibody Name: | CYP2U1 Antibody (PACO22049) |
| Antibody SKU: | PACO22049 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from internal of human Cytochrome P450 2U1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells and Lovo cells, using Cytochrome P450 2U1 antibody. |
| Background: | Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. |
| Synonyms: | Cytochrome P450 2U1; EC 1.14.14.1; CP2U1; |
| UniProt Protein Function: | CYP2U1: Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Oxidoreductase; Membrane protein, integral; EC 1.14.14.1; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 4q25 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane Molecular Function:iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; oxygen binding Biological Process: organic acid metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process Disease: Spastic Paraplegia 56, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z449 |
| NCBI GenInfo Identifier: | 74762432 |
| NCBI Gene ID: | 113612 |
| NCBI Accession: | Q7Z449.1 |
| UniProt Secondary Accession: | Q7Z449,Q96EQ6, B2RMV7, |
| UniProt Related Accession: | Q7Z449 |
| Molecular Weight: | 18,578 Da |
| NCBI Full Name: | Cytochrome P450 2U1 |
| NCBI Synonym Full Names: | cytochrome P450, family 2, subfamily U, polypeptide 1 |
| NCBI Official Symbol: | CYP2U1Â Â |
| NCBI Official Synonym Symbols: | SPG49; SPG56; P450TECÂ Â |
| NCBI Protein Information: | cytochrome P450 2U1; spastic paraplegia 49 |
| UniProt Protein Name: | Cytochrome P450 2U1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2U1Â Â |
| UniProt Entry Name: | CP2U1_HUMAN |
