The DEAF1 Polyclonal Antibody (PAC019552) is a powerful tool designed for research involving DEAF1, a transcription factor involved in gene regulation and immune function. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, such as Western blot and immunohistochemistry.DEAF1 is known to play a crucial role in immune response modulation and has been implicated in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By targeting DEAF1 with this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies.Overall, the DEAF1 Polyclonal Antibody offers researchers a reliable tool for studying DEAF1 expression and function in a variety of cell types and tissues, making it an ideal choice for studies in immunology, cancer research, and beyond.
Antibody Name:
DEAF1 Antibody (PACO19552)
Antibody SKU:
PACO19552
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human DEAF1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19552(DEAF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19552(DEAF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
Synonyms:
DEAF1 transcription factor
UniProt Protein Function:
DEAF1: a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleusMolecular Function: protein binding; transcription factor activityBiological Process: anatomical structure morphogenesis; embryonic skeletal development; germ cell development; negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription, DNA-dependent; regulation of mammary gland epithelial cell proliferation; regulation of transcription from RNA polymerase II promoterDisease: Mental Retardation, Autosomal Dominant 24
UniProt Protein Details:
NCBI Summary:
This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
