The DGKH Polyclonal Antibody (PAC023260) is a valuable tool for researchers studying the DGKH gene, which plays a crucial role in various cellular processes, including lipid metabolism and signal transduction. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot experiments.DGKH, known as diacylglycerol kinase eta, is involved in the conversion of diacylglycerol to phosphatidic acid, a key step in lipid signaling pathways. Dysregulation of DGKH has been linked to conditions such as bipolar disorder and schizophrenia, making it an important target for research in the field of neuroscience and mental health.
By utilizing the DGKH Polyclonal Antibody, researchers can investigate the expression levels and localization of DGKH in various cell types and tissues, providing valuable insights into its function and potential implications in disease pathology. This antibody is a valuable resource for studies aiming to understand the molecular mechanisms underlying neurological disorders and lipid-related diseases.
Synthesized peptide derived from internal of human DGKH.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using DGKH antibody.
Immunofluorescence analysis of HeLa cells, using DGKH antibody.
Background:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Synonyms:
iacylglycerol kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta; DAG kinase eta
