The DGKI Polyclonal Antibody (PAC023177) is a valuable tool for researchers studying DGKI, a protein involved in various cellular processes, including signaling pathways and lipid metabolism. This antibody is produced in rabbits, offering high reactivity with human samples and suitability for Western blot applications. By specifically binding to DGKI, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology, signal transduction, and lipid signaling pathways.DGKI has been identified as a key player in lipid metabolism and signal transduction processes, making it an attractive target for research into metabolic disorders, neurodegenerative diseases, and cancer.
By investigating the function and regulation of DGKI, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify new therapeutic targets for intervention. The DGKI Polyclonal Antibody is a valuable tool for unraveling the complexities of DGKI biology and advancing our understanding of its role in health and disease.
Synthesized peptide derived from C-terminal of human DGKI.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using DGKI antibody.
Immunofluorescence analysis of HeLa cells, using DGKI antibody.
Background:
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration.
Synonyms:
DAG kinase iota; DGK-IOTA; DGK-iota; DGKI; EC 2.7.1.107
UniProt Protein Function:
DGKI: a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
Molecular Function:diacylglycerol kinase activity; protein binding
Biological Process: platelet activation
NCBI Summary:
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
