The DGKK Polyclonal Antibody (PAC013431) is a high-quality research tool for studying DGKK protein, an enzyme involved in lipid metabolism and signaling pathways. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting applications. By targeting the DGKK protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in lipid biology and signal transduction.DGKK, also known as diacylglycerol kinase kappa, plays a crucial role in the regulation of lipid signaling pathways that control various cellular functions, including cell growth, differentiation, and survival.
Dysregulation of DGKK has been implicated in metabolic disorders and cancer development, making it a promising target for research into potential therapeutic interventions. Understanding the function of DGKK is essential for unraveling its role in disease pathogenesis and identifying novel drug targets for improving patient outcomes.
DGKK: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Belongs to the eukaryotic diacylglycerol kinase family.Protein type: EC 2.7.1.107; Kinase, lipidChromosomal Location of Human Ortholog: Xp11.22Cellular Component: cytoplasm; plasma membraneMolecular Function: ATP binding; diacylglycerol kinase activity; metal ion bindingBiological Process: blood coagulation; diacylglycerol metabolic process; phosphorylation; platelet activation; protein kinase C activation; response to oxidative stress
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
