Description
DLX4 Antibody (PACO08860)
The DLX4 Polyclonal Antibody (PACO08860) is a vital tool for researchers studying the DLX4 protein, a transcription factor known for its role in developmental processes, specifically in the formation of various tissues and organs. This highly specific antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot and immunohistochemistry applications.DLX4 is a crucial regulator of gene expression, controlling the development and differentiation of various cell types. It plays a significant role in embryogenesis, particularly in the development of the central nervous system and craniofacial structures.
Research on DLX4 is essential for understanding its function in normal development and its potential implications in diseases such as congenital malformations and certain cancers.With its ability to target and detect the DLX4 protein, this antibody is an invaluable tool for investigating the mechanisms underlying developmental processes and diseases related to DLX4 dysregulation. By studying the activity of DLX4, researchers can gain insights into its impact on cellular processes and potentially uncover new therapeutic targets for developmental disorders and cancer.
| Antibody Name: | DLX4 Antibody (PACO08860) |
| Antibody SKU: | PACO08860 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human DLX4 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | distal-less homeobox 4;DLX4;BP1;DLX7;DLX8;DLX9 ; |
| UniProt Protein Function: | DLX4: May play a role in determining the production of hemoglobin S. May act as a repressor. Belongs to the distal-less homeobox family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.33 Molecular Function:protein binding; sequence-specific DNA binding Biological Process: negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92988 |
| NCBI GenInfo Identifier: | 85700416 |
| NCBI Gene ID: | 1748 |
| NCBI Accession: | Q92988.4 |
| UniProt Secondary Accession: | Q92988,O60480, Q13265, Q6PJK0, Q9HBE0, D3DTX2, D3DTX3 |
| UniProt Related Accession: | Q92988 |
| Molecular Weight: | 12,713 Da |
| NCBI Full Name: | Homeobox protein DLX-4 |
| NCBI Synonym Full Names: | distal-less homeobox 4 |
| NCBI Official Symbol: | DLX4Â Â |
| NCBI Official Synonym Symbols: | BP1; DLX7; DLX8; DLX9; OFC15Â Â |
| NCBI Protein Information: | homeobox protein DLX-4 |
| UniProt Protein Name: | Homeobox protein DLX-4 |
| UniProt Synonym Protein Names: | Beta protein 1; Homeobox protein DLX-7; Homeobox protein DLX-8 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | DLX4Â Â |
| UniProt Entry Name: | DLX4_HUMAN |
