The DLX4 Polyclonal Antibody (PACO16190) is an essential tool for researchers studying DLX4, a transcription factor involved in embryonic development and cell differentiation. This antibody is produced in rabbits and is highly specific for DLX4 in human samples, making it an ideal choice for a variety of research applications, including Western blot analysis.DLX4 is known to regulate the expression of genes involved in skeletal and craniofacial development, making it a key player in developmental biology research. Additionally, DLX4 has been implicated in various cancers, suggesting its potential as a therapeutic target in cancer treatment.
By using the DLX4 Polyclonal Antibody, researchers can gain valuable insights into the function of DLX4 in these contexts and potentially uncover novel therapeutic strategies.Overall, the DLX4 Polyclonal Antibody is a valuable tool for researchers interested in studying DLX4's role in development, cancer, and other biological processes. Its high reactivity and specificity make it a reliable option for investigating the functions of DLX4 in various cell types and tissues, pushing forward our understanding of this important transcription factor.
Antibody Name:
DLX4 Antibody (PACO16190)
Antibody SKU:
PACO16190
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human DLX4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16190(DLX4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16190(DLX4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
Synonyms:
distal-less homeobox 4
UniProt Protein Function:
DLX4: May play a role in determining the production of hemoglobin S. May act as a repressor. Belongs to the distal-less homeobox family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.33
Molecular Function:protein binding; sequence-specific DNA binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
NCBI Summary:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
