The DLX4 Polyclonal Antibody (PAC016191) is a valuable tool for research involving DLX4, a transcription factor known for its role in development and differentiation processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including immunofluorescence and immunohistochemistry.DLX4 is a key player in the regulation of gene expression during embryonic development, particularly in the formation of organs and tissues. Its dysregulation has been associated with a range of developmental disorders and cancers, highlighting the importance of studying its function.
The DLX4 antibody enables the detection and localization of DLX4 protein in cells and tissues, providing valuable insights for researchers in developmental biology and oncology.Overall, the DLX4 Polyclonal Antibody is a reliable tool for investigating the function and expression of DLX4 in various contexts, furthering our understanding of its role in development and disease.
Antibody Name:
DLX4 Antibody (PACO16191)
Antibody SKU:
PACO16191
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human DLX4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO16191(DLX4 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
Background:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
Synonyms:
distal-less homeobox 4
UniProt Protein Function:
DLX4: May play a role in determining the production of hemoglobin S. May act as a repressor. Belongs to the distal-less homeobox family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.33
Molecular Function:protein binding; sequence-specific DNA binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
NCBI Summary:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
