The DMRT3 Monoclonal Antibody (PACO16192) is a valuable tool for researchers studying the DMRT3 protein, which is involved in the development of neural circuits controlling limb movement in vertebrates. This antibody, produced in mice, is highly specific to DMRT3 and has been validated for use in immunohistochemistry and Western blot applications. It binds specifically to the DMRT3 protein, allowing for detection and analysis in various tissues and cell types.DMRT3 is essential for the formation of neural pathways that coordinate limb movement, making it a key player in motor control and coordination.
Research on DMRT3 is crucial for understanding developmental disorders that affect movement, such as spasticity and paralysis, as well as for exploring potential therapeutic targets for neurological conditions.Overall, the DMRT3 Monoclonal Antibody (PACO16192) is a reliable tool for investigating the role of DMRT3 in neural development and motor function, with potential applications in neuroscience, developmental biology, and neurology research.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16192(DMRT3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse stomach tissue, Mouse brain tissue, Primary antibody: PACO16192(DMRT3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16192(DMRT3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid, protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Synonyms:
doublesex and mab-3 related transcription factor 3
