The DNAI2 Polyclonal Antibody (PACO05041) is a valuable tool for researchers studying DNAI2, a protein involved in ciliary motility and respiratory function. This antibody, produced in rabbits, is highly specific for human DNAI2 and has been validated for use in Western blot applications. By binding to the DNAI2 protein, this antibody enables researchers to detect and analyze DNAI2 expression in various cell types, making it ideal for studies in respiratory biology and genetic disorders affecting ciliary function.DNAI2 is a key player in maintaining the proper function of cilia, hair-like structures on the surface of cells that play essential roles in cellular motility and signaling.
Mutations in DNAI2 have been linked to primary ciliary dyskinesia, a genetic disorder that affects the function of cilia in the respiratory system, leading to recurrent infections and respiratory issues. By studying DNAI2 and its role in ciliary function, researchers can gain valuable insights into the mechanisms underlying ciliary motility and potential therapeutic targets for ciliary-related diseases.
Antibody Name:
DNAI2 Antibody (PACO05041)
Antibody SKU:
PACO05041
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the N-terminal region of human Dynein IC2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
DNAI2: Part of the dynein complex of respiratory cilia. Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein intermediate chain family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motor; Motility/polarity/chemotaxis; Microtubule-bindingChromosomal Location of Human Ortholog: 17q25Cellular Component: microtubule; axonemal dynein complex; axonemeMolecular Function: protein binding; microtubule motor activityBiological Process: metabolic process; cilium biogenesisDisease: Ciliary Dyskinesia, Primary, 9
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
