The DNAI2 Polyclonal Antibody (PACO08869) is a valuable tool for researchers studying the DNAI2 protein, which is essential for the proper function of cilia in the respiratory tract. This antibody, developed using rabbits as the host species, shows high reactivity specifically with human samples and has been validated for use in Western blot applications.The DNAI2 protein is involved in the movement of cilia, which play a crucial role in clearing mucus and debris from the airways. Dysfunctions in DNAI2 have been linked to various respiratory conditions, making it a target of interest in the study of respiratory diseases such as primary ciliary dyskinesia (PCD).
By binding to the DNAI2 protein, this antibody enables precise detection and analysis of DNAI2 expression levels in various cell types, providing researchers with the means to investigate the role of DNAI2 in ciliary function and respiratory health. Its utility in immunology and respiratory research makes it a valuable tool for advancing our understanding of ciliary dysfunction and its implications in respiratory diseases.
DNAI2: Part of the dynein complex of respiratory cilia. Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein intermediate chain family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motor; Motility/polarity/chemotaxis; Microtubule-bindingChromosomal Location of Human Ortholog: 17q25Cellular Component: microtubule; axonemal dynein complex; axonemeMolecular Function: protein binding; microtubule motor activityBiological Process: metabolic process; cilium biogenesisDisease: Ciliary Dyskinesia, Primary, 9
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
