Description
DOK3 Antibody (PACO00719)
The DOK3 Polyclonal Antibody (PACO00719) is a valuable tool for researchers studying DOK3, a key signaling molecule involved in immune regulation and cell activation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot experiments. By targeting the DOK3 protein, this antibody enables scientists to detect and analyze DOK3 expression in various cell types, making it an essential component for studies in immunology and cancer research.DOK3, also known as downstream of kinase 3, is a critical regulator of immune responses, playing a key role in cell signaling pathways that control inflammation and immune cell activation.
Its involvement in these processes positions DOK3 as a significant target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By investigating the function of DOK3, researchers can gain valuable insights that may lead to the development of novel therapies aimed at modulating immune responses in a variety of disease contexts.
| Antibody Name: | DOK3 Antibody |
| Antibody SKU: | PACO00719 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human Dok-3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | DOK3; Docking protein 3; Downstream of tyrosine kinase 3 |
| UniProt Protein Function: | DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts with CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q35.3 Molecular Function:protein binding |
| UniProt Code: | Q7L591 |
| NCBI GenInfo Identifier: | 84029599 |
| NCBI Gene ID: | 79930 |
| NCBI Accession: | Q7L591.2 |
| UniProt Secondary Accession: | Q7L591,Q8N864, Q9BQB3, Q9H666, E9PAT0, H7BXS0, |
| UniProt Related Accession: | Q7L591 |
| Molecular Weight: | 24,737 Da |
| NCBI Full Name: | Docking protein 3 |
| NCBI Synonym Full Names: | docking protein 3 |
| NCBI Official Symbol: | DOK3Â Â |
| NCBI Official Synonym Symbols: | DOKLÂ Â |
| NCBI Protein Information: | docking protein 3 |
| UniProt Protein Name: | Docking protein 3 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 3 |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK3Â Â |
| UniProt Entry Name: | DOK3_HUMAN |
