The DTX3 Polyclonal Antibody (PAC014338) is a specialized antibody designed for research involving DTX3, a protein involved in various cellular functions, including cell cycle regulation and apoptosis. This antibody, produced in rabbits, boasts high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the DTX3 protein, researchers can easily detect and analyze its presence in different cell types, making it an ideal tool for studies in cell biology and cancer research.
DTX3, also known as deltex E3 ubiquitin ligase 3, plays a crucial role in regulating the degradation of specific target proteins, thereby influencing important cellular processes. Its involvement in pathways related to cell proliferation and survival makes it a promising target for investigation in cancer research and therapeutic development. Understanding the function of DTX3 can provide valuable insights into the molecular mechanisms underlying tumorigenesis and potential therapeutic strategies targeting this protein.
Antibody Name:
DTX3 Antibody (PACO14338)
Antibody SKU:
PACO14338
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human DTX3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO14338(DTX3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes.
Background:
DTX3 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context By similarity. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms:
Deltex homolog 3 (Drosophila)
UniProt Protein Function:
DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-Chromosomal Location of Human Ortholog: 12q13.3Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
