The DXO Antibody (PACO08918) is a highly specific polyclonal antibody designed for research involving DXO, a protein involved in RNA metabolism and RNA decay processes. This antibody, generated in rabbits, is optimized for use in various experimental applications, including Western blotting and immunofluorescence.DXO, a RNA exonuclease, plays a crucial role in removing aberrant structures from the 5' end of RNA molecules, thereby regulating RNA stability and decay. Dysregulation of DXO has been linked to RNA metabolism-related diseases, making it a key target for research in areas such as cancer biology, neurodegenerative disorders, and viral infections.
This antibody is validated for its specificity and sensitivity in detecting DXO protein levels in human samples, enabling researchers to study the function and regulation of DXO in different cell types and experimental settings. By understanding the role of DXO in RNA decay pathways, researchers can gain insights into disease mechanisms and potentially identify novel therapeutic targets for various RNA-related disorders.
DOM3Z: May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA. Belongs to the Dom3Z family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 6p21.3Cellular Component: cytoplasm; nucleus; plasma membraneMolecular Function: 5'-3' exonuclease activity; magnesium ion binding; mRNA bindingBiological Process: metabolic process; mRNA catabolic process; RNA destabilization
UniProt Protein Details:
NCBI Summary:
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
