The DYRK1B Polyclonal Antibody (PACO08969) is a valuable tool for researchers studying the DYRK1B protein, a key regulator of cell growth and proliferation. This antibody, produced in rabbits, specifically recognizes DYRK1B in human samples and is validated for use in Western blot applications. By binding to DYRK1B, this antibody allows for the detection and analysis of this important protein in various cell types.DYRK1B is known to play a critical role in cell cycle regulation and is implicated in a variety of diseases, including cancer and neurodegenerative disorders.
By studying the function of DYRK1B, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets. The DYRK1B Polyclonal Antibody is a valuable tool for investigating the role of this protein in disease pathogenesis and could lead to the development of new treatment strategies.
DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding; protein kinase activity; transcription coactivator activityBiological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylationDisease: Abdominal Obesity-metabolic Syndrome 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
