The ECEL1 Polyclonal Antibody (PACO08984) is a valuable tool for researchers studying the ECEL1 protein, a key player in neuronal development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ECEL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and neurodevelopmental disorders.
ECEL1, also known as endothelin-converting enzyme-like 1, is essential for proper nerve growth and communication within the nervous system. Dysregulation of ECEL1 has been linked to neurological conditions such as neuropathies and neurodegenerative diseases, making it a promising target for therapeutic research. Understanding the role of ECEL1 in neuronal function is crucial for developing treatments that address these disorders and promote overall brain health.
ECEL1: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Belongs to the peptidase M13 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; EC 3.4.24.-; Membrane protein, integralChromosomal Location of Human Ortholog: 2q37.1Cellular Component: integral to plasma membraneMolecular Function: metallopeptidase activityBiological Process: respiratory system processDisease: Arthrogryposis, Distal, Type 5d
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
