Description
EFEMP1 Antibody (PACO02703)
The EFEMP1 Antibody (PACO02703) is a valuable tool for researchers studying EFEMP1, a protein associated with extracellular matrix assembly and cell adhesion. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in a variety of applications, including Western blotting.EFEMP1, also known as fibulin-3, plays a key role in maintaining the structural integrity of tissues and is implicated in various disease contexts, including cancer and age-related macular degeneration.
By targeting EFEMP1 with this antibody, researchers can investigate its functional roles in cell signaling, migration, and proliferation, providing valuable insights into disease mechanisms and potential therapeutic strategies.Overall, the EFEMP1 Antibody (PACO02703) is a powerful tool for studying the biology of EFEMP1 and its implications in disease, making it essential for research in areas such as cancer biology, tissue engineering, and regenerative medicine.
| Antibody Name: | EFEMP1 Antibody |
| Antibody SKU: | PACO02703 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Fibulin-3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | EFEMP1; FBLN3; FBNL; EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3 |
| UniProt Protein Function: | EFEMP1: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD); also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: extracellular matrix; extracellular region; extracellular space Molecular Function:epidermal growth factor receptor activity; epidermal growth factor receptor binding; protein binding Biological Process: camera-type eye development; embryonic eye morphogenesis; epidermal growth factor receptor signaling pathway; negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; post-embryonic eye morphogenesis; regulation of transcription, DNA-dependent; visual perception Disease: Doyne Honeycomb Retinal Dystrophy |
| NCBI Summary: | This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] |
| UniProt Code: | Q12805 |
| NCBI GenInfo Identifier: | 9973182 |
| NCBI Gene ID: | 2202 |
| NCBI Accession: | Q12805.2 |
| UniProt Secondary Accession: | Q12805,Q541U7, A8K3I4, B4DW75, D6W5D2, |
| UniProt Related Accession: | Q12805 |
| Molecular Weight: | 39,195 Da |
| NCBI Full Name: | EGF-containing fibulin-like extracellular matrix protein 1 |
| NCBI Synonym Full Names: | EGF containing fibulin like extracellular matrix protein 1 |
| NCBI Official Symbol: | EFEMP1Â Â |
| NCBI Official Synonym Symbols: | DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3Â Â |
| NCBI Protein Information: | EGF-containing fibulin-like extracellular matrix protein 1 |
| UniProt Protein Name: | EGF-containing fibulin-like extracellular matrix protein 1 |
| UniProt Synonym Protein Names: | Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3 |
| UniProt Gene Name: | EFEMP1Â Â |
