The EFNA2 Polyclonal Antibody (PACO00766) is a valuable tool for researchers studying Ephrin A2, a critical cell surface protein involved in neuronal development and axon guidance. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting EFNA2 in human samples, making it a reliable option for Western blot applications. By targeting EFNA2, researchers can investigate its role in nervous system development, angiogenesis, and tumorigenesis.Ephrin A2, a member of the Eph family of receptor tyrosine kinases, plays a crucial role in mediating cell-to-cell communication and signaling pathways.
Its involvement in neuronal migration and guidance makes it an intriguing target for studies focused on neurodevelopmental disorders, cancer metastasis, and angiogenesis. Through the use of the EFNA2 Polyclonal Antibody, researchers can gain valuable insights into the functions of EFNA2 and its implications in various physiological and pathological processes.
Antibody Name:
EFNA2 Antibody
Antibody SKU:
PACO00766
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the N-terminal region of human Ephrin-A2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: extracellular region; plasma membrane; perikaryon; neuromuscular junctionMolecular Function: ephrin receptor bindingBiological Process: axon guidance; cell-cell signaling; olfactory bulb development; ephrin receptor signaling pathway; osteoclast differentiation; bone remodeling
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
