Description
EFNA4 Antibody (PACO00768)
The EFNA4 Polyclonal Antibody (PACO00768) is a valuable tool for researchers studying EFNA4, a member of the ephrin family of cell surface proteins involved in cell signaling and development. This antibody, produced in rabbits, is highly specific to human EFNA4 and has been validated for use in various applications, including Western blot and immunofluorescence.EFNA4 plays a critical role in mediating cell-cell communication and is known to be involved in processes such as axon guidance, angiogenesis, and neuronal migration.
Dysregulation of EFNA4 expression has been implicated in various diseases, including cancer, neurodevelopmental disorders, and cardiovascular diseases. The EFNA4 Polyclonal Antibody enables researchers to study the expression and localization of EFNA4 in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications.
| Antibody Name: | EFNA4 Antibody |
| Antibody SKU: | PACO00768 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Ephrin-A4. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | EFNA4; EPLG4; LERK4; Ephrin-A4; EPH-related receptor tyrosine kinase ligand 4; LERK-4 |
| UniProt Protein Function: | EFNA4: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: extracellular region; integral to plasma membrane; plasma membrane Molecular Function:ephrin receptor binding; protein binding; transmembrane-ephrin receptor activity Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52798 |
| NCBI GenInfo Identifier: | 3821237 |
| NCBI Gene ID: | 1945 |
| NCBI Accession: | CAA06993.1 |
| UniProt Secondary Accession: | P52798,O95457, Q5SR71, Q6FI57, C9JHJ8, G3XAK2, |
| UniProt Related Accession: | P52798 |
| Molecular Weight: | 22,584 Da |
| NCBI Full Name: | ephrin-A4 |
| NCBI Synonym Full Names: | ephrin-A4 |
| NCBI Official Symbol: | EFNA4Â Â |
| NCBI Official Synonym Symbols: | EFL4; EPLG4; LERK4Â Â |
| NCBI Protein Information: | ephrin-A4 |
| UniProt Protein Name: | Ephrin-A4 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 4; LERK-4 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNA4Â Â |
| UniProt Entry Name: | EFNA4_HUMAN |
