The EGFL8 Antibody (PAC014368) is a polyclonal antibody designed for research involving EGFL8, an epidermal growth factor (EGF)-like protein involved in various cellular processes such as cell proliferation, migration, and angiogenesis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.EGFL8, also known as MAEG, plays a crucial role in promoting tumor growth and metastasis in several cancer types. Its overexpression is associated with poor patient prognosis, making it a potential target for cancer therapy.
Additionally, EGFL8 has been implicated in the regulation of vascular development and may be a target for anti-angiogenic therapy.The EGFL8 Antibody enables the detection and analysis of EGFL8 protein expression in various cell types and tissues, making it a valuable tool for researchers studying cancer biology, angiogenesis, and other cellular processes. Understanding the function of EGFL8 could lead to the development of novel therapeutic strategies for cancer treatment and other diseases.
Antibody Name:
EGFL8 Antibody (PACO14368)
Antibody SKU:
PACO14368
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human EGFL8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14368(EGFL8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14368(EGFL8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion, and neural and vertebrate development. EGFL8 (EGF-like domain-containing protein 8), also known as C6orf8, NG3 and VE-statin-2, is a 293 amino acid, secreted protein that contains two EGF-like domains and one EMI domain. Via its EGF and EMI domains, EGFL8 may participate in protein-protein interactions that correlate with cellular proliferation and developmental signaling events. In mice, EGFL8 is expressed predominately in brain, kidney, lung and thymus.
Synonyms:
EGF-like-domain, multiple 8
UniProt Protein Function:
EGFL8: Protein type: Calcium-binding; Membrane protein, integral; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 6p21.32Cellular Component: extracellular regionMolecular Function: calcium ion bindingBiological Process: in utero embryonic development
