The EML4 Polyclonal Antibody (PAC053162) is a vital tool for researchers studying the EML4 protein, which is known for its involvement in cancer progression, particularly in non-small cell lung cancer. This antibody is raised in rabbits and has been validated for use in Western blot applications with high reactivity towards human samples.EML4, short for echinoderm microtubule-associated protein-like 4, is a fusion partner with the ALK gene in a subset of lung cancers, leading to constitutive activation of the ALK signaling pathway.
Understanding the role of EML4 in cancer development and progression is crucial for developing targeted therapies for patients with EML4-ALK fusion-positive tumors.The EML4 Polyclonal Antibody enables precise detection and analysis of EML4 protein expression in various cell types, making it an essential tool for cancer research. By studying the function of EML4, researchers can uncover new insights into the molecular mechanisms of cancer and potentially identify novel therapeutic targets for improved patient outcomes.
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate. All lanes: EML4 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 109, 103 kDa. Observed band size: 109 kDa.
Background:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
