The EP300 Polyclonal Antibody is a crucial tool for researchers studying the role of EP300, a key player in gene transcription and cell signaling. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the EP300 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for research in fields such as molecular biology, cancer biology, and developmental biology.EP300, also known as E1A binding protein p300, is a histone acetyltransferase that plays a critical role in regulating gene expression and cellular processes such as cell cycle progression and DNA repair.
Dysregulation of EP300 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. Understanding the function of EP300 is crucial for developing targeted therapies and interventions aimed at restoring proper cellular function and addressing disease pathology.In summary, the EP300 Polyclonal Antibody is a valuable asset for researchers looking to delve deep into the intricate mechanisms of gene regulation and cell signaling mediated by the EP300 protein. Its high specificity and reliability make it an indispensable tool for advancing our understanding of cellular processes and disease mechanisms.
Product Name:
EP300 Polyclonal Antibody
SKU:
CAB24352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 940-1030 of human EP300(NP_001420.2).
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Purification Method:
Affinity purification
Gene ID:
2033
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of EP300 in paraffin-embedded rat colon tissue using EP300 Rabbit pAb (CAB24352) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.
