The ERAS Antibody (PAC019614) offered by Assay Genie is a valuable tool for research involving ERAS, a protein associated with invasion and migration of cancer cells. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the ERAS protein, this antibody allows for accurate detection and analysis in different cell types, making it ideal for studies in cancer biology and metastasis research.
ERAS, also known as the Embryonic RAS protein, is a key player in promoting tumor progression and metastasis in cancer. Understanding the mechanisms underlying ERAS function is essential for developing targeted therapies to combat cancer spread and improve patient outcomes. The ERAS Antibody from Assay Genie provides researchers with a reliable tool to investigate the role of ERAS in tumor biology, paving the way for the development of novel anti-cancer strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19614(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO19614(ERAS Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19614(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance.
Synonyms:
ES cell expressed Ras
UniProt Protein Function:
ERas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Belongs to the small GTPase superfamily. Ras family.Protein type: G protein, monomeric, Ras; G protein, monomeric; G proteinChromosomal Location of Human Ortholog: Xp11.23
UniProt Protein Details:
NCBI Summary:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
