The ERGIC1 Polyclonal Antibody (PAC038914) is a reliable tool for researchers studying ERGIC1, a key protein involved in protein trafficking and localization within the cell's endoplasmic reticulum-Golgi intermediate compartment (ERGIC). This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human ERGIC1 samples, making it suitable for various applications such as Western blotting.ERGIC1 plays a vital role in maintaining the proper function of the secretory pathway and protein transport within the cell. Dysregulation of ERGIC1 has been implicated in various diseases related to protein misfolding and trafficking defects, including neurodegenerative disorders and metabolic syndromes.
By using the ERGIC1 Polyclonal Antibody, researchers can explore the mechanisms underlying these pathological conditions and potentially develop targeted therapies for them.This antibody's ability to target ERGIC1 protein opens up opportunities for studying protein trafficking dynamics, organelle interactions, and intracellular signaling pathways. With its high specificity and sensitivity, the ERGIC1 Polyclonal Antibody is a valuable tool for advancing research in cell biology, neurology, and metabolic diseases.
Western blot. All lanes: ERGIC1 antibody at 2µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33, 23, 18 kDa. Observed band size: 33 kDa.
Immunofluorescent analysis of HepG2 cells using PACO38914 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human colon cancer using PACO38914 at dilution of 1:100.
Background:
Possible role in transport between endoplasmic reticulum and Golgi.
ERGIC1: Possible role in transport between endoplasmic reticulum and Golgi. Belongs to the ERGIC family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5q35.1Cellular Component: Golgi membrane; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; membrane; ER-Golgi intermediate compartment; integral to membraneMolecular Function: protein bindingBiological Process: ER to Golgi vesicle-mediated transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]
