The CRM1/XPO1 Antibody (CAB0299) is a high-quality antibody developed for reliable detection and analysis of target proteins. Exportin 1, also known as XPO1, is a protein involved in nuclear export of various molecules, including proteins and RNA. This antibody, developed through rabbit immunization, specifically targets Exportin 1 in human samples, allowing for efficient detection and analysis in Western blot experiments.Exportin 1 plays a crucial role in the regulation of gene expression and cellular signaling by controlling the transport of macromolecules between the nucleus and cytoplasm. Dysregulation of Exportin 1 has been linked to various diseases, including cancer, making it a promising target for therapeutic intervention.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
CRM1/XPO1 Antibody
SKU:
CAB0299
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Purification Method
Affinity purification
Gene ID
7514
RRID
AB_2757111
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CAbGn1/XPO1 Rabbit pAb (CAB0299) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
