FABP4 Antibody (PACO09187)
- SKU:
- PACO09187
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | FABP4 Antibody (PACO09187) |
| Antibody SKU: | PACO09187 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human FABP4 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | fatty acid, binding protein 4, adipocyte;FABP4;A-FABP;aP2 ; |
| UniProt Protein Function: | FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 8q21 Cellular Component: cytoplasm; lipid particle; nucleus Molecular Function:transporter activity; fatty acid binding Biological Process: cholesterol homeostasis; transport; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; negative regulation of protein kinase activity; cytokine production; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response |
| NCBI Summary: | FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15090 |
| NCBI GenInfo Identifier: | 119781 |
| NCBI Gene ID: | 2167 |
| NCBI Accession: | P15090.3 |
| UniProt Secondary Accession: | P15090,Q6IBA1, |
| UniProt Related Accession: | P15090 |
| Molecular Weight: | 132 |
| NCBI Full Name: | Fatty acid-binding protein, adipocyte |
| NCBI Synonym Full Names: | fatty acid binding protein 4, adipocyte |
| NCBI Official Symbol: | FABP4 |
| NCBI Official Synonym Symbols: | aP2; ALBP; AFABP; A-FABP; HEL-S-104 |
| NCBI Protein Information: | fatty acid-binding protein, adipocyte; fatty acid-binding protein 4; adipocyte lipid-binding protein; epididymis secretory protein Li 104; adipocyte-type fatty acid-binding protein |
| UniProt Protein Name: | Fatty acid-binding protein, adipocyte |
| UniProt Synonym Protein Names: | Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4 |
| Protein Family: | Fatty acid-binding protein |
| UniProt Gene Name: | FABP4 |
| UniProt Entry Name: | FABP4_HUMAN |
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