The FAM13B Polyclonal Antibody (PACO19644) is a crucial tool for researchers studying FAM13B, a protein known for its role in regulating cellular processes and signaling pathways. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the FAM13B protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and disease research.FAM13B, also referred to as a putative inositol polyphosphate 1-phosphatase, is involved in various cellular functions, such as cell proliferation, migration, and apoptosis.
Its significance in regulating key signaling pathways makes it an attractive target for research into conditions like cancer, cardiovascular diseases, and neurodegenerative disorders. Understanding the mechanisms by which FAM13B operates is essential for developing targeted therapies that can modulate its activity and potentially treat associated diseases effectively.
Antibody Name:
FAM13B Antibody (PACO19644)
Antibody SKU:
PACO19644
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human FAM13B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19644(FAM13B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19644(FAM13B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FAM13B is a 915 amino acid, protein that is encoded by a gene that maps to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Synonyms:
family with sequence similarity 13, member B
UniProt Protein Function:
FAM13B: a protein that contains 1 Rho-GAP domain.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 5q31Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: positive regulation of defense response to virus by host; regulation of small GTPase mediated signal transduction
