The FAM35A Polyclonal Antibody (PACO4646) is a vital tool for researchers delving into the functions of the FAM35A protein, a key player in various cellular processes. This antibody, produced in rabbits, exhibits a high level of reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FAM35A protein, this antibody facilitates the detection and analysis of FAM35A in a range of cell types, making it indispensable for investigations in cell biology and molecular biology.
FAM35A, also known as family with sequence similarity 35 member A, is known to be involved in diverse cellular functions such as cell development, proliferation, and signaling pathways. Its significance in these processes positions it as a promising target for research exploring conditions related to cell growth, differentiation, and disease progression. Unraveling the biological roles of FAM35A can provide valuable insights for the development of potential therapeutic interventions targeting these cellular pathways.
Antibody Name:
FAM35A Antibody
Antibody SKU:
PACO04646
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human FAM35A/B.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
FAM35A; Protein FAM35A; FAM35B; Protein FAM35B
UniProt Protein Function:
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
