The FAM35A/FAM35-B Antibody (PAC022523) is a highly specific monoclonal antibody designed for research involving FAM35A and FAM35-B, two related proteins that play important roles in cellular function. This antibody, produced and validated for use in various applications, is ideal for studying the function and localization of FAM35A and FAM35-B in different cell types.FAM35A and FAM35-B are involved in cellular processes such as transcription regulation, cell cycle progression, and DNA repair. Understanding their functions can provide valuable insights into various biological processes and diseases.
This antibody, validated for use in techniques such as immunofluorescence and immunoprecipitation, can aid researchers in studying the roles of FAM35A and FAM35-B in cancer biology, neurobiology, and other fields of research.With its high specificity and reliability in detecting FAM35A and FAM35-B, the FAM35A/FAM35-B Antibody (PAC022523) is a valuable tool for researchers looking to investigate the functions and mechanisms of these proteins in cellular physiology and disease pathology.
Antibody Name:
FAM35AFAM35/B Antibody (PACO22523)
Antibody SKU:
PACO22523
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human FAM35A/B.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using FAM35A/B antibody.
Background:
Belongs to the FAM35 family. 2 isoforms of the human protein are produced by alternative splicing.
Synonyms:
Protein FAM35A; Protein FAM35B;
UniProt Protein Function:
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
